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由于油脂分泌旺盛，如果皮肤表面堆积的油脂清理不及时或不干净，毛囊口就会被堵住，皮脂腺分泌的油脂只能堆积在毛囊内，当毛囊内堵塞物过多时就会横向发展，撑大毛囊导致毛孔粗大。
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熬夜有双重致痘因素，一方面油脂分泌旺盛，皮肤一油就容易堵，毛囊堵塞后就相当于给厌氧菌创造了繁殖的条件，导致细菌大量繁殖引发炎症，出现长痘；另一方面是熬夜会导致体内热毒炽盛（肝火旺），容易在眉心和太阳穴位置爆痘。
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five. Warrior Survival.io - This battle royale recreation worries players to get the final one standing on an island full of other gamers.
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2. Snake io War - This snake activity problems players to mature their snake by feeding on glowing orbs when staying away from other snakes.
对于经常熬夜的患者，体内的激素水平会发生紊乱，此时可能会导致皮肤的油脂分泌旺盛，当皮脂腺分泌的大量油脂无法顺利排出，堵塞在毛囊孔内便形成痘痘。并且对于经常熬夜的患者，机体的抵抗力会发生下降，此时痘痘也比较容易受到细菌的感染从而加重。
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